best way to make regions?

I want to make a region between 2 points with a way of checking if a player breaks a block in that region. What is the best way to go about this that will cause the least amount of lag or hopefully no lag.

 

Make use of Object Oriented Programing. Create a new class that has the variables for a region.

Code:

public class Region {
 
private int startX;
private int startY;
private int startZ;
 
private int endX;
private int endY;
private int endZ;
 
public Region(int startX) {
this.startX = startX;
//ect, ect
}
//Create getters and setters
} 

Create a Set<Region> (look into Java generics if you don't understand this).
regionSet.add(new Region(1, 2, 3, 4, 5, 6));

 

PHP:

    @EventHandler
    public void blockBreak(BlockBreakEvent e) {
        //block 1
        int minX = 0;
        int minY = 0;
        int minZ = 0;
       
        //block 2
        int maxX = 0;
        int maxY = 0;
        int maxZ = 0;
        Location l = e.getBlock().getLocation();
        if (l.getBlockX() >= minX && l.getBlockX() <= maxX) {
            if (l.getBlockY() >= minY && l.getBlockY() <= maxY) {
                if (l.getBlockZ() >= minZ && l.getBlockZ() <= maxZ) {
                    //block is within region
                }
            }
        }
        //extra:
        for (int x=minX;x<maxX;x++) {
            for(int y=minY;y<maxY;y++) {
                for (int z=minZ;z<maxZ;z++) {
                    //do something for every block in the region
                }
            }
        }
    }

My crap way of doing regions